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Research

The Department of Pathology is deeply invested in scientific efforts to improve treatments in our field. Learn more about our department’s investigations below.

Message from the Vice Chair

"We are driven by a shared passion for discovery and a deep commitment to advancing human health through innovative research programs and collaborative partnerships among scientists and pathologists."

Peng Ji, MD, PhD
Vice Chair of Research 

Read Full Message

Areas of Research

Members of the Department of Pathology are defining the cellular and molecular basis of disease toward the development of new and improved strategies to diagnose and treat, inherited, acquired and infectious disorders. Learn more about the work being done in our labs via the descriptions below.

Affilated Research Centers and Institutes

The faculty members of Northwestern University Feinberg School of Medicine’s Department of Pathology are engaged in research within the department and throughout Northwestern Medicine and Northwestern University. Our work throughout the community, including director appointments, illustrate the importance we put on scientific collaboration.

Research Cores

Core facilities provide cost-efficient access of state-of-the-art equipment, the most current technologies and expert technical advice to individual scientists.

Learn more about our affiliated cores

Recent Publications

Genetic Underpinnings of Cuticular Hydrocarbon Biosynthesis in the German Cockroach, Blattella germanica (L.): Progress and Perspectives.

Pei XJ, Schal C, Fan YL.

J Chem Ecol. 2024 May 10. doi: 10.1007/s10886-024-01509-7. Online ahead of print.

Histologic Features of Mycobacterial Spindle Cell Pseudotumors: A Multi-institutional Clinicopathologic Analysis of 14 Cases.

Szczepanski JM, Lieberman JA, Lamps LW, Gonzalez RS, Xue Y, Zhang X, Yilmaz OH, Hart J, Krausz T, Mantilla JG, McHugh JB, Westerhoff M.

Am J Surg Pathol. 2024 May 10. doi: 10.1097/PAS.0000000000002234. Online ahead of print.

Adrenal pheochromocytoma impacts three main pathways: cysteine-methionine, pyrimidine, and tyrosine metabolism.

Lai C, Yang Q, Zhang Y, Gong R, Wang M, Li J, Lai M, Sun Q.

J Zhejiang Univ Sci B. 2024 Mar 12;25(5):410-421. doi: 10.1631/jzus.B2300579.

Exploring the properties and potential of the neural extracellular matrix for next-generation regenerative therapies.

Ortega JA, Soares de Aguiar GP, Chandravanshi P, Levy N, Engel E, Álvarez Z.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2024 May-Jun;16(3):e1962. doi: 10.1002/wnan.1962.

Mitochondria regulate proliferation in adult cardiac myocytes.

Waypa GB, Smith KA, Mungai PT, Dudley VJ, Helmin KA, Singer BD, Peek CB, Bass J, Beussink-Nelson L, Shah SJ, Ofman G, Wasserstrom JA, Muller WA, Misharin AV, Budinger GRS, Abdala-Valencia H, Chandel NS, Dokic D, Bartom ET, Zhang S, Tatekoshi Y, Mahmoodzadeh A, Ardehali H, Thorp EB, Schumacker PT.

J Clin Invest. 2024 May 9:e165482. doi: 10.1172/JCI165482. Online ahead of print.

Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design.

Gross RS, Thaweethai T, Rosenzweig EB, Chan J, Chibnik LB, Cicek MS, Elliott AJ, Flaherman VJ, Foulkes AS, Gage Witvliet M, Gallagher R, Gennaro ML, Jernigan TL, Karlson EW, Katz SD, Kinser PA, Kleinman LC, Lamendola-Essel MF, Milner JD, Mohandas S, Mudumbi PC, Newburger JW, Rhee KE, Salisbury AL, Snowden JN, Stein CR, Stockwell MS, Tantisira KG, Thomason ME, Truong DT, Warburton D, Wood JC, Ahmed S, Akerlundh A, Alshawabkeh AN, Anderson BR, Aschner JL, Atz AM, Aupperle RL, Baker FC, Balaraman V, Banerjee D, Barch DM, Baskin-Sommers A, Bhuiyan S, Bind MC, Bogie AL, Bradford T, Buchbinder NC, Bueler E, Bükülmez H, Casey BJ, Chang L, Chrisant M, Clark DB, Clifton RG, Clouser KN, Cottrell L, Cowan K, D'Sa V, Dapretto M, Dasgupta S, Dehority W, Dionne A, Dummer KB, Elias MD, Esquenazi-Karonika S, Evans DN, Faustino EVS, Fiks AG, Forsha D, Foxe JJ, Friedman NP, Fry G, Gaur S, Gee DG, Gray KM, Handler S, Harahsheh AS, Hasbani K, Heath AC, Hebson C, Heitzeg MM, Hester CM, Hill S, Hobart-Porter L, Hong TKF, Horowitz CR, Hsia DS, Huentelman M, Hummel KD, Irby K, Jacobus J, Jacoby VL, Jone PN, Kaelber DC, Kasmarcak TJ, Kluko MJ, Kosut JS, Laird AR, Landeo-Gutierrez J, Lang SM, Larson CL, Li… See abstract for full author list ➔

PLoS One. 2024 May 7;19(5):e0285635. doi: 10.1371/journal.pone.0285635. eCollection 2024.

Longitudinal Trajectories of Biomarkers of Kidney Tubular Function in Type 1 Diabetes.

Limonte CP, Gao X, Bebu I, Seegmiller JC, Lorenzi GM, Perkins BA, Karger AB, Arends VL, Paterson A, Molitch ME, de Boer IH; DCCT/EDIC Research Group.

Kidney Int Rep. 2024 Feb 18;9(5):1406-1418. doi: 10.1016/j.ekir.2023.11.030. eCollection 2024 May.

Hippocampal aggregation signatures of pathogenic UBQLN2 in amyotrophic lateral sclerosis and frontotemporal dementia.

Thumbadoo KM, Dieriks BV, Murray HC, Swanson MEV, Yoo JH, Mehrabi NF, Turner C, Dragunow M, Faull RLM, Curtis MA, Siddique T, Shaw CE, Newell KL, Henden L, Williams KL, Nicholson GA, Scotter EL.

Brain. 2024 May 4:awae140. doi: 10.1093/brain/awae140. Online ahead of print.

Genome sequence analyses identify novel risk loci for multiple system atrophy.

Chia R, Ray A, Shah Z, Ding J, Ruffo P, Fujita M, Menon V, Saez-Atienzar S, Reho P, Kaivola K, Walton RL, Reynolds RH, Karra R, Sait S, Akcimen F, Diez-Fairen M, Alvarez I, Fanciulli A, Stefanova N, Seppi K, Duerr S, Leys F, Krismer F, Sidoroff V, Zimprich A, Pirker W, Rascol O, Foubert-Samier A, Meissner WG, Tison F, Pavy-Le Traon A, Pellecchia MT, Barone P, Russillo MC, Marín-Lahoz J, Kulisevsky J, Torres S, Mir P, Periñán MT, Proukakis C, Chelban V, Wu L, Goh YY, Parkkinen L, Hu MT, Kobylecki C, Saxon JA, Rollinson S, Garland E, Biaggioni I, Litvan I, Rubio I, Alcalay RN, Kwei KT, Lubbe SJ, Mao Q, Flanagan ME, Castellani RJ, Khurana V, Ndayisaba A, Calvo A, Mora G, Canosa A, Floris G, Bohannan RC, Moore A, Norcliffe-Kaufmann L, Palma JA, Kaufmann H, Kim C, Iba M, Masliah E, Dawson TM, Rosenthal LS, Pantelyat A, Albert MS, Pletnikova O, Troncoso JC, Infante J, Lage C, Sánchez-Juan P, Serrano GE, Beach TG, Pastor P, Morris HR, Albani D, Clarimon J, Wenning GK, Hardy JA, Ryten M, Topol E, Torkamani A, Chiò A, Bennett DA, De Jager PL, Low PA, Singer W, Cheshire WP, Wszolek ZK, Dickson DW, Traynor BJ, Gibbs JR, Dalgard CL, Ross OA, Houlden H, Scholz SW.

Neuron. 2024 Apr 24:S0896-6273(24)00240-X. doi: 10.1016/j.neuron.2024.04.002. Online ahead of print.

Response of treatment-naive brain metastases to stereotactic radiosurgery.

Ene CI, Abi Faraj C, Beckham TH, Weinberg JS, Andersen CR, Haider AS, Rao G, Ferguson SD, Alvarez-Brenkenridge CA, Kim BYS, Heimberger AB, McCutcheon IE, Prabhu SS, Wang CM, Ghia AJ, McGovern SL, Chung C, McAleer MF, Tom MC, Perni S, Swanson TA, Yeboa DN, Briere TM, Huse JT, Fuller GN, Lang FF, Li J, Suki D, Sawaya RE.

Nat Commun. 2024 May 2;15(1):3728. doi: 10.1038/s41467-024-47998-8.

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